<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019b443e-fe2c-7df5-8007-164a4174a56e,g:08033206-6d84-41bd-a4fc-673e5e1827e2-->
<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:meso="http://www.mesoblast.com/20251231" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:dtr-types1="http://www.xbrl.org/dtr/type/2022-03-31" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2024-01-31" attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://www.mesoblast.com/20251231">
  <xs:import namespace="http://fasb.org/srt/2025" schemaLocation="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2022-03-31" schemaLocation="https://www.xbrl.org/dtr/type/2022-03-31/types.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd"/>
  <xs:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/currency/2025" schemaLocation="https://xbrl.sec.gov/currency/2025/currency-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei/2025" schemaLocation="https://xbrl.sec.gov/dei/2025/dei-2025.xsd"/>
  <xs:import namespace="https://xbrl.ifrs.org/taxonomy/2025-03-27/ifrs-full" schemaLocation="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd"/>
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="meso-20251231_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="meso-20251231_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="meso-20251231_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="meso-20251231_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple"/>
      <link:roleType id="DocumentandEntityInformation" roleURI="http://www.mesoblast.com/role/DocumentandEntityInformation">
        <link:definition>0000001 - Document - Document and Entity Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedIncomeStatementunaudited" roleURI="http://www.mesoblast.com/role/CondensedConsolidatedIncomeStatementunaudited">
        <link:definition>9952151 - Statement - Condensed Consolidated Income Statement (unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedIncomeStatementunauditedParenthetical" roleURI="http://www.mesoblast.com/role/CondensedConsolidatedIncomeStatementunauditedParenthetical">
        <link:definition>9952152 - Statement - Condensed Consolidated Income Statement (unaudited) (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementofComprehensiveIncomeunaudited" roleURI="http://www.mesoblast.com/role/CondensedConsolidatedStatementofComprehensiveIncomeunaudited">
        <link:definition>9952153 - Statement - Condensed Consolidated Statement of Comprehensive Income (unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementofChangesinEquity" roleURI="http://www.mesoblast.com/role/CondensedConsolidatedStatementofChangesinEquity">
        <link:definition>9952154 - Statement - Condensed Consolidated Statement of Changes in Equity</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedBalanceSheetunaudited" roleURI="http://www.mesoblast.com/role/CondensedConsolidatedBalanceSheetunaudited">
        <link:definition>9952155 - Statement - Condensed Consolidated Balance Sheet (unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CondensedConsolidatedStatementofCashFlowsunaudited" roleURI="http://www.mesoblast.com/role/CondensedConsolidatedStatementofCashFlowsunaudited">
        <link:definition>9952156 - Statement - Condensed Consolidated Statement of Cash Flows (unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Basisofpreparation" roleURI="http://www.mesoblast.com/role/Basisofpreparation">
        <link:definition>9952157 - Disclosure - Basis of preparation</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Significantchangesinthecurrentreportingperiod" roleURI="http://www.mesoblast.com/role/Significantchangesinthecurrentreportingperiod">
        <link:definition>9952158 - Disclosure - Significant changes in the current reporting period</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Lossbeforeincometax" roleURI="http://www.mesoblast.com/role/Lossbeforeincometax">
        <link:definition>9952159 - Disclosure - Loss before income tax</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Incometaxbenefitexpense" roleURI="http://www.mesoblast.com/role/Incometaxbenefitexpense">
        <link:definition>9952160 - Disclosure - Income tax benefit/(expense)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Financialassetsandliabilities" roleURI="http://www.mesoblast.com/role/Financialassetsandliabilities">
        <link:definition>9952161 - Disclosure - Financial assets and liabilities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Nonfinancialassetsandliabilities" roleURI="http://www.mesoblast.com/role/Nonfinancialassetsandliabilities">
        <link:definition>9952162 - Disclosure - Non-financial assets and liabilities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Cashflowinformation" roleURI="http://www.mesoblast.com/role/Cashflowinformation">
        <link:definition>9952163 - Disclosure - Cash flow information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Equity" roleURI="http://www.mesoblast.com/role/Equity">
        <link:definition>9952164 - Disclosure - Equity</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Financialriskmanagement" roleURI="http://www.mesoblast.com/role/Financialriskmanagement">
        <link:definition>9952165 - Disclosure - Financial risk management</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Lossespershare" roleURI="http://www.mesoblast.com/role/Lossespershare">
        <link:definition>9952166 - Disclosure - Losses per share</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Eventsoccurringafterthereportingperiod" roleURI="http://www.mesoblast.com/role/Eventsoccurringafterthereportingperiod">
        <link:definition>9952167 - Disclosure - Events occurring after the reporting period</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Segmentinformation" roleURI="http://www.mesoblast.com/role/Segmentinformation">
        <link:definition>9952168 - Disclosure - Segment information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofpreparationPolicies" roleURI="http://www.mesoblast.com/role/BasisofpreparationPolicies">
        <link:definition>9955511 - Disclosure - Basis of preparation (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LossbeforeincometaxTables" roleURI="http://www.mesoblast.com/role/LossbeforeincometaxTables">
        <link:definition>9955512 - Disclosure - Loss before income tax (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncometaxbenefitexpenseTables" roleURI="http://www.mesoblast.com/role/IncometaxbenefitexpenseTables">
        <link:definition>9955513 - Disclosure - Income tax benefit/(expense) (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesTables" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesTables">
        <link:definition>9955514 - Disclosure - Financial assets and liabilities (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesTables" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesTables">
        <link:definition>9955515 - Disclosure - Non-financial assets and liabilities (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CashflowinformationTables" roleURI="http://www.mesoblast.com/role/CashflowinformationTables">
        <link:definition>9955516 - Disclosure - Cash flow information (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EquityTables" roleURI="http://www.mesoblast.com/role/EquityTables">
        <link:definition>9955517 - Disclosure - Equity (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialriskmanagementTables" roleURI="http://www.mesoblast.com/role/FinancialriskmanagementTables">
        <link:definition>9955518 - Disclosure - Financial risk management (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LossespershareTables" roleURI="http://www.mesoblast.com/role/LossespershareTables">
        <link:definition>9955519 - Disclosure - Losses per share (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofpreparationDetails" roleURI="http://www.mesoblast.com/role/BasisofpreparationDetails">
        <link:definition>9955520 - Disclosure - Basis of preparation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SignificantchangesinthecurrentreportingperiodDetails" roleURI="http://www.mesoblast.com/role/SignificantchangesinthecurrentreportingperiodDetails">
        <link:definition>9955521 - Disclosure - Significant changes in the current reporting period (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LossbeforeincometaxSummaryofLossBeforeIncomeTaxDetails" roleURI="http://www.mesoblast.com/role/LossbeforeincometaxSummaryofLossBeforeIncomeTaxDetails">
        <link:definition>9955522 - Disclosure - Loss before income tax - Summary of Loss Before Income Tax (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LossbeforeincometaxAdditionalInformationDetails" roleURI="http://www.mesoblast.com/role/LossbeforeincometaxAdditionalInformationDetails">
        <link:definition>9955523 - Disclosure - Loss before income tax - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncometaxbenefitexpenseSummaryofIncomeTaxExpenseBenefitDetails" roleURI="http://www.mesoblast.com/role/IncometaxbenefitexpenseSummaryofIncomeTaxExpenseBenefitDetails">
        <link:definition>9955524 - Disclosure - Income tax benefit/(expense) - Summary of Income Tax Expense/(Benefit) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncometaxbenefitexpenseSummaryofDeferredTaxAssetsNotBroughttoAccountDetails" roleURI="http://www.mesoblast.com/role/IncometaxbenefitexpenseSummaryofDeferredTaxAssetsNotBroughttoAccountDetails">
        <link:definition>9955525 - Disclosure - Income tax benefit/(expense) - Summary of Deferred Tax Assets Not Brought to Account (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofFinancialInstrumentsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofFinancialInstrumentsDetails">
        <link:definition>9955526 - Disclosure - Financial assets and liabilities - Summary of Financial Instruments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofCashandCashEquivalentsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofCashandCashEquivalentsDetails">
        <link:definition>9955527 - Disclosure - Financial assets and liabilities - Summary of Cash and Cash Equivalents (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofTradeandOtherReceivablesDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofTradeandOtherReceivablesDetails">
        <link:definition>9955528 - Disclosure - Financial assets and liabilities - Summary of Trade and Other Receivables (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofPrepaymentsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofPrepaymentsDetails">
        <link:definition>9955529 - Disclosure - Financial assets and liabilities - Summary of Prepayments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesAdditionalInformationTradeandOtherReceivablesDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesAdditionalInformationTradeandOtherReceivablesDetails">
        <link:definition>9955530 - Disclosure - Financial assets and liabilities - Additional Information Trade and Other Receivables (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofTradeandOtherPayablesDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofTradeandOtherPayablesDetails">
        <link:definition>9955531 - Disclosure - Financial assets and liabilities - Summary of Trade and Other Payables (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofBorrowingsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofBorrowingsDetails">
        <link:definition>9955532 - Disclosure - Financial assets and liabilities - Summary of Borrowings (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesAdditionalInformationBorrowingsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesAdditionalInformationBorrowingsDetails">
        <link:definition>9955533 - Disclosure - Financial assets and liabilities - Additional Information Borrowings (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofNetDebtDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofNetDebtDetails">
        <link:definition>9955534 - Disclosure - Financial assets and liabilities - Summary of Net Debt (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofNetDebtReconciliationDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofNetDebtReconciliationDetails">
        <link:definition>9955535 - Disclosure - Financial assets and liabilities - Summary of Net Debt Reconciliation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofFinancialAssetsandLiabilitiesMeasuredandRecognizedatFairValueDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofFinancialAssetsandLiabilitiesMeasuredandRecognizedatFairValueDetails">
        <link:definition>9955536 - Disclosure - Financial assets and liabilities - Summary of Financial Assets and Liabilities Measured and Recognized at Fair Value (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesAdditionalInformationFairvaluemeasurementsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesAdditionalInformationFairvaluemeasurementsDetails">
        <link:definition>9955537 - Disclosure - Financial assets and liabilities - Additional Information, Fair value measurements (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofChangesinFairValueofLevel3InstrumentsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofChangesinFairValueofLevel3InstrumentsDetails">
        <link:definition>9955538 - Disclosure - Financial assets and liabilities - Summary of Changes in Fair Value of Level 3 Instruments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofQuantitativeInformationAbouttheSignificantUnobservableInputsUsedinLevel3FairValueMeasurementsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofQuantitativeInformationAbouttheSignificantUnobservableInputsUsedinLevel3FairValueMeasurementsDetails">
        <link:definition>9955539 - Disclosure - Financial assets and liabilities - Summary of Quantitative Information About the Significant Unobservable Inputs Used in Level 3 Fair Value Measurements (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofValuationProcessesofContingentConsiderationatFairValueDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofValuationProcessesofContingentConsiderationatFairValueDetails">
        <link:definition>9955540 - Disclosure - Financial assets and liabilities - Summary of Valuation Processes of Contingent Consideration at Fair Value (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesAdditionalInformationValuationProcessedofContingentConsiderationDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesAdditionalInformationValuationProcessedofContingentConsiderationDetails">
        <link:definition>9955541 - Disclosure - Financial assets and liabilities - Additional Information, Valuation Processed of Contingent Consideration (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofFairValueOfContingentConsiderationDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofFairValueOfContingentConsiderationDetails">
        <link:definition>9955542 - Disclosure - Financial assets and liabilities - Summary of Fair Value Of Contingent Consideration (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofWarrantLiabilityDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofWarrantLiabilityDetails">
        <link:definition>9955543 - Disclosure - Financial assets and liabilities - Summary of Warrant Liability (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesAdditionalInformationWarrantsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesAdditionalInformationWarrantsDetails">
        <link:definition>9955544 - Disclosure - Financial assets and liabilities - Additional Information Warrants (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialassetsandliabilitiesSummaryofFairValueofWarrantsDetails" roleURI="http://www.mesoblast.com/role/FinancialassetsandliabilitiesSummaryofFairValueofWarrantsDetails">
        <link:definition>9955545 - Disclosure - Financial assets and liabilities - Summary of Fair Value of Warrants (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesSummaryofIntangibleAssetsDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesSummaryofIntangibleAssetsDetails">
        <link:definition>9955546 - Disclosure - Non-financial assets and liabilities - Summary of Intangible Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesSummaryofCarryingValueofInProcessResearchandDevelopmentAcquiredbyProductDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesSummaryofCarryingValueofInProcessResearchandDevelopmentAcquiredbyProductDetails">
        <link:definition>9955547 - Disclosure - Non-financial assets and liabilities - Summary of Carrying Value of In Process Research and Development Acquired by Product (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesSummaryofProvisionsDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesSummaryofProvisionsDetails">
        <link:definition>9955548 - Disclosure - Non-financial assets and liabilities - Summary of Provisions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesAdditionalInformationProvisionsDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesAdditionalInformationProvisionsDetails">
        <link:definition>9955549 - Disclosure - Non-financial assets and liabilities - Additional Information, Provisions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesSummaryofDeferredTaxBalancesDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesSummaryofDeferredTaxBalancesDetails">
        <link:definition>9955550 - Disclosure - Non-financial assets and liabilities - Summary of Deferred Tax Balances (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesSummaryofMovementsRelatedtoDeferredTaxAssetsandLiabilitiesDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesSummaryofMovementsRelatedtoDeferredTaxAssetsandLiabilitiesDetails">
        <link:definition>9955551 - Disclosure - Non-financial assets and liabilities - Summary of Movements Related to Deferred Tax Assets and Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesSummaryofInventoriesDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesSummaryofInventoriesDetails">
        <link:definition>9955552 - Disclosure - Non-financial assets and liabilities - Summary of Inventories (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NonfinancialassetsandliabilitiesAdditionalInformationInventoryDetails" roleURI="http://www.mesoblast.com/role/NonfinancialassetsandliabilitiesAdditionalInformationInventoryDetails">
        <link:definition>9955553 - Disclosure - Non-financial assets and liabilities - Additional Information, Inventory (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CashflowinformationDetails" roleURI="http://www.mesoblast.com/role/CashflowinformationDetails">
        <link:definition>9955554 - Disclosure - Cash flow information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EquityScheduleofShareCapitalDetails" roleURI="http://www.mesoblast.com/role/EquityScheduleofShareCapitalDetails">
        <link:definition>9955555 - Disclosure - Equity - Schedule of Share Capital (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EquitySummaryofMovementsinOrdinaryShareCapitalDetails" roleURI="http://www.mesoblast.com/role/EquitySummaryofMovementsinOrdinaryShareCapitalDetails">
        <link:definition>9955556 - Disclosure - Equity - Summary of Movements in Ordinary Share Capital (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EquitySummaryofMovementsofSharesinShareTrustDetails" roleURI="http://www.mesoblast.com/role/EquitySummaryofMovementsofSharesinShareTrustDetails">
        <link:definition>9955557 - Disclosure - Equity - Summary of Movements of Shares in Share Trust (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EquitySummaryofWarrantReserveDetails" roleURI="http://www.mesoblast.com/role/EquitySummaryofWarrantReserveDetails">
        <link:definition>9955558 - Disclosure - Equity - Summary of Warrant Reserve (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EquityAdditionalInformationDetails" roleURI="http://www.mesoblast.com/role/EquityAdditionalInformationDetails">
        <link:definition>9955559 - Disclosure - Equity - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialriskmanagementAdditionalInformationDetails" roleURI="http://www.mesoblast.com/role/FinancialriskmanagementAdditionalInformationDetails">
        <link:definition>9955560 - Disclosure - Financial risk management - Additional Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialriskmanagementSummaryofDepositsHeldwhichDeriveInterestRevenueTogetherwiththeMaximumandMinimumInterestRatesBeingEarnedDetails" roleURI="http://www.mesoblast.com/role/FinancialriskmanagementSummaryofDepositsHeldwhichDeriveInterestRevenueTogetherwiththeMaximumandMinimumInterestRatesBeingEarnedDetails">
        <link:definition>9955561 - Disclosure - Financial risk management - Summary of Deposits Held which Derive Interest Revenue Together with the Maximum and Minimum Interest Rates Being Earned (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialriskmanagementSummaryofBorrowingtoPriceRateChangesDetails" roleURI="http://www.mesoblast.com/role/FinancialriskmanagementSummaryofBorrowingtoPriceRateChangesDetails">
        <link:definition>9955562 - Disclosure - Financial risk management - Summary of Borrowing to Price Rate Changes (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialriskmanagementSummaryofWarrantLiabilitiesIncreaseorDecreaseSharePriceOthervariablesDetails" roleURI="http://www.mesoblast.com/role/FinancialriskmanagementSummaryofWarrantLiabilitiesIncreaseorDecreaseSharePriceOthervariablesDetails">
        <link:definition>9955563 - Disclosure - Financial risk management - Summary of Warrant Liabilities Increase or Decrease Share Price Other variables (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FinancialriskmanagementSummaryofMaturityProfileofAnticipatedFutureContractualCashFlowsCarryingValueDetails" roleURI="http://www.mesoblast.com/role/FinancialriskmanagementSummaryofMaturityProfileofAnticipatedFutureContractualCashFlowsCarryingValueDetails">
        <link:definition>9955564 - Disclosure - Financial risk management - Summary of Maturity Profile of Anticipated Future Contractual Cash Flows Carrying Value (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LossespershareDetails" roleURI="http://www.mesoblast.com/role/LossespershareDetails">
        <link:definition>9955565 - Disclosure - Losses per share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SegmentInformationDetails" roleURI="http://www.mesoblast.com/role/SegmentInformationDetails">
        <link:definition>9955566 - Disclosure - Segment Information (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:element id="meso_FairValueRemeasurementOfContingentConsideration" abstract="false" name="FairValueRemeasurementOfContingentConsideration" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_FairValueRemeasurementOfWarrantLiability" abstract="false" name="FairValueRemeasurementOfWarrantLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_CurrentMarketedProductsMember" abstract="true" name="CurrentMarketedProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_InvestmentRevaluationReserveMember" abstract="true" name="InvestmentRevaluationReserveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_IncreaseThroughContributionsByOwnersForUnissuedOrdinarySharesEquity" abstract="false" name="IncreaseThroughContributionsByOwnersForUnissuedOrdinarySharesEquity" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TaxCreditedOrDebitedToEquity" abstract="false" name="TaxCreditedOrDebitedToEquity" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_CurrentProvisionsAndOtherCurrentLiabilities" abstract="false" name="CurrentProvisionsAndOtherCurrentLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_NoncurrentProvisionsAndOtherNoncurrentLiabilities" abstract="false" name="NoncurrentProvisionsAndOtherNoncurrentLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DeferredConsiderationNonCurrent" abstract="false" name="DeferredConsiderationNonCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_PaymentsToSuppliersAndEmployeesInclusiveOfGoodsAndServicesTax" abstract="false" name="PaymentsToSuppliersAndEmployeesInclusiveOfGoodsAndServicesTax" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_GovernmentGrantsAndTaxIncentivesAndCreditsReceived" abstract="false" name="GovernmentGrantsAndTaxIncentivesAndCreditsReceived" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_PaymentsForReceiptsFromInvestmentInSublease" abstract="false" name="PaymentsForReceiptsFromInvestmentInSublease" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ReceiptOfSecurityDeposits" abstract="false" name="ReceiptOfSecurityDeposits" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ProceedsFromIssuingWarrants" abstract="false" name="ProceedsFromIssuingWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_PaymentsOfTransactionCostsFromBorrowings" abstract="false" name="PaymentsOfTransactionCostsFromBorrowings" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_InterestAndOtherCostsOfFinancePaidClassifiedAsFinancingActivities" abstract="false" name="InterestAndOtherCostsOfFinancePaidClassifiedAsFinancingActivities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ProceedsFromIssuingSharesAndOtherEquityInstruments" abstract="false" name="ProceedsFromIssuingSharesAndOtherEquityInstruments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_PaymentForShareAndOtherEquitySecuritiesIssueCosts" abstract="false" name="PaymentForShareAndOtherEquitySecuritiesIssueCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ProceedsFromSettlementOfLeaseLiabilitiesClassifiedAsFinancingActivities" abstract="false" name="ProceedsFromSettlementOfLeaseLiabilitiesClassifiedAsFinancingActivities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_BasisOfPreparationAbstract" abstract="true" name="BasisOfPreparationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfSignificantChangesInCurrentReportingPeriodAbstract" abstract="true" name="DisclosureOfSignificantChangesInCurrentReportingPeriodAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfSignificantChangesInCurrentReportingPeriodExplanatoryTextBlock" abstract="false" name="DisclosureOfSignificantChangesInCurrentReportingPeriodExplanatoryTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfLossBeforeIncomeTaxAbstract" abstract="true" name="DisclosureOfLossBeforeIncomeTaxAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfDetailedInformationAboutLossBeforeIncomeTaxExplanatoryTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutLossBeforeIncomeTaxExplanatoryTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfFinancialAssetsAndLiabilitiesAbstract" abstract="true" name="DisclosureOfFinancialAssetsAndLiabilitiesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfFinancialAssetsAndFinancialLiabilitiesExplanatoryTextBlock" abstract="false" name="DisclosureOfFinancialAssetsAndFinancialLiabilitiesExplanatoryTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfNonFinancialAssetsAndLiabilitiesAbstract" abstract="true" name="DisclosureOfNonFinancialAssetsAndLiabilitiesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfNonFinancialAssetsAndNonFinancialLiabilitiesExplanatoryTextBlock" abstract="false" name="DisclosureOfNonFinancialAssetsAndNonFinancialLiabilitiesExplanatoryTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_CashFlowInformationAbstract" abstract="true" name="CashFlowInformationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfFinancialRiskManagementAbstract" abstract="true" name="DisclosureOfFinancialRiskManagementAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DescriptionOfAccountingPolicyForBasisOfPreparationExplanatoryPolicyTextBlock" abstract="false" name="DescriptionOfAccountingPolicyForBasisOfPreparationExplanatoryPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfLossBeforeIncomeTaxExplanatoryTableTextBlock" abstract="false" name="DisclosureOfLossBeforeIncomeTaxExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfDetailedInformationAboutIncomeTaxExplanatoryTableTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutIncomeTaxExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfDeferredTaxAssetsNotBroughtToAccountExplanatoryTableTextBlock" abstract="false" name="DisclosureOfDeferredTaxAssetsNotBroughtToAccountExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfTradeAndOtherReceivablesAndPrepaymentsExplanatoryTableTextBlock" abstract="false" name="DisclosureOfTradeAndOtherReceivablesAndPrepaymentsExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfDetailedInformationAboutNetDebtExplanatoryTableTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutNetDebtExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfDetailedInformationAboutNetDebtReconciliationExplanatoryTableTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutNetDebtReconciliationExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfDetailedInformationAboutFairValueMeasurementExplanatoryTableTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutFairValueMeasurementExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfSignificantUnobservableInputsUsedInFairValueMeasurementOfAssetsAndLiabilitiesExplanatoryTableTextBlock" abstract="false" name="DisclosureOfSignificantUnobservableInputsUsedInFairValueMeasurementOfAssetsAndLiabilitiesExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfQuantitativeInformationAboutSignificantUnobservableInputsUsedInFairValueMeasurementsExplanatoryTableTextBlock" abstract="false" name="DisclosureOfQuantitativeInformationAboutSignificantUnobservableInputsUsedInFairValueMeasurementsExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfDetailedInformationAboutValuationProcessesOfContingentConsiderationAtFairValueExplanatoryTableTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutValuationProcessesOfContingentConsiderationAtFairValueExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfDetailedInformationAboutWarrantLiabilityExplanatoryTableTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutWarrantLiabilityExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfDetailedInformationAboutFairValueOfWarrantsExplanatoryTableTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutFairValueOfWarrantsExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfCarryingValueOfInProcessResearchAndDevelopmentAcquiredByProductExplanatoryTableTextBlock" abstract="false" name="DisclosureOfCarryingValueOfInProcessResearchAndDevelopmentAcquiredByProductExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfNetMovementRelatedToDeferredTaxAssetsAndLiabilitiesExplanatoryTableTextBlock" abstract="false" name="DisclosureOfNetMovementRelatedToDeferredTaxAssetsAndLiabilitiesExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfSummaryOfCashFlowInformationExplanatoryTableTextBlock" abstract="false" name="DisclosureOfSummaryOfCashFlowInformationExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfMovementsInOrdinaryShareCapitalExplanatoryTableTextBlock" abstract="false" name="DisclosureOfMovementsInOrdinaryShareCapitalExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfMovementsOfSharesInShareTrustExplanatoryTableTextBlock" abstract="false" name="DisclosureOfMovementsOfSharesInShareTrustExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfExposureToFinancialRisksTableTextBlock" abstract="false" name="DisclosureOfExposureToFinancialRisksTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfDepositsHeldWhichDeriveInterestRevenueWithMaximumAndMinimumInterestRatesBeingEarnedExplanatoryTableTextBlock" abstract="false" name="DisclosureOfDepositsHeldWhichDeriveInterestRevenueWithMaximumAndMinimumInterestRatesBeingEarnedExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfBorrowingsDerivingPriceRiskExplanatoryTableTextBlock" abstract="false" name="DisclosureOfBorrowingsDerivingPriceRiskExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_DisclosureOfSensitivityAnalysisEffectOfIncreaseDecreaseInSharePriceTableTextBlock" abstract="false" name="DisclosureOfSensitivityAnalysisEffectOfIncreaseDecreaseInSharePriceTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="meso_CreditLineFacilityMember" abstract="true" name="CreditLineFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_BorrowingFacilitiesMaximumBorrowingCapacity" abstract="false" name="BorrowingFacilitiesMaximumBorrowingCapacity" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_BorrowingsMaturityTerm" abstract="false" name="BorrowingsMaturityTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_BorrowingFacilitiesRemainingBorrowingCapacity" abstract="false" name="BorrowingFacilitiesRemainingBorrowingCapacity" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_SeniorDebtFacilityMember" abstract="true" name="SeniorDebtFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_LoanAndSecurityAgreementMember" abstract="true" name="LoanAndSecurityAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_OaktreeCapitalManagementLPMember" abstract="true" name="OaktreeCapitalManagementLPMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_NovaQuestCapitalManagementLLCMember" abstract="true" name="NovaQuestCapitalManagementLLCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_AmericanDepositarySharesMember" abstract="true" name="AmericanDepositarySharesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_NumberOfWarrantsGrantedToPurchaseShares" abstract="false" name="NumberOfWarrantsGrantedToPurchaseShares" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="meso_NumberOfWarrantsGrantedToPurchaseAmericanDepositaryShares" abstract="false" name="NumberOfWarrantsGrantedToPurchaseAmericanDepositaryShares" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_WarrantsPricePerShare" abstract="false" name="WarrantsPricePerShare" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="meso_PercentageOfPremiumForVolumeWeightedAveragePrice" abstract="false" name="PercentageOfPremiumForVolumeWeightedAveragePrice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_DisclosureOfLossBeforeIncomeTaxTable" abstract="true" name="DisclosureOfLossBeforeIncomeTaxTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_IncomeStatementLocationsAxis" abstract="true" name="IncomeStatementLocationsAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_IncomeStatementLocationMember" abstract="true" name="IncomeStatementLocationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_IncomeStatementFunctionalExpenseCategoriesMember" abstract="true" name="IncomeStatementFunctionalExpenseCategoriesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ResearchAndDevelopmentMember" abstract="true" name="ResearchAndDevelopmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_DisclosureOfLossBeforeIncomeTaxLineItems" abstract="true" name="DisclosureOfLossBeforeIncomeTaxLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_ClinicalTrialRelatedResearchAndDevelopmentExpense" abstract="false" name="ClinicalTrialRelatedResearchAndDevelopmentExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ManufacturingProductionAndDevelopmentExpense" abstract="false" name="ManufacturingProductionAndDevelopmentExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_CommercializationExpense" abstract="false" name="CommercializationExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DefinedContributionSuperannuationExpenses" abstract="false" name="DefinedContributionSuperannuationExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DepreciationAndAmortizationOfNonCurrentAssetsAbstract" abstract="true" name="DepreciationAndAmortizationOfNonCurrentAssetsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DepreciationPropertyPlantAndEquipmentIncludingLossOnDisposalsOfPropertyPlantAndEquipment" abstract="false" name="DepreciationPropertyPlantAndEquipmentIncludingLossOnDisposalsOfPropertyPlantAndEquipment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_IntellectualPropertyAmortization" abstract="false" name="IntellectualPropertyAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_OtherManagementAndAdministrationExpensesAbstract" abstract="true" name="OtherManagementAndAdministrationExpensesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_OverheadsAndAdministrationExpenses" abstract="false" name="OverheadsAndAdministrationExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ConsultancyExpenses" abstract="false" name="ConsultancyExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_LegalAndOtherProfessionalFees" abstract="false" name="LegalAndOtherProfessionalFees" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_IntellectualPropertyExpenses" abstract="false" name="IntellectualPropertyExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_OtherManagementAndAdministrationExpenses" abstract="false" name="OtherManagementAndAdministrationExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_FairValueRemeasurementOfContingentConsiderationAbstract" abstract="true" name="FairValueRemeasurementOfContingentConsiderationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_GainsLossesOnRemeasurementOfContingentConsideration" abstract="false" name="GainsLossesOnRemeasurementOfContingentConsideration" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_FairValueRemeasurementOfWarrantLiabilityAbstract" abstract="true" name="FairValueRemeasurementOfWarrantLiabilityAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_LossGainOnRemeasurementOfWarrantLiability" abstract="false" name="LossGainOnRemeasurementOfWarrantLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_OtherOperatingIncomeAndExpensesAbstract" abstract="true" name="OtherOperatingIncomeAndExpensesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_ForeignExchangeGainsLosses" abstract="false" name="ForeignExchangeGainsLosses" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ForeignWithholdingTaxesPaid" abstract="false" name="ForeignWithholdingTaxesPaid" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_FinanceCostsGainsAbstract" abstract="true" name="FinanceCostsGainsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_FinanceCostsGainsOnRemeasurementOfBorrowingArrangements" abstract="false" name="FinanceCostsGainsOnRemeasurementOfBorrowingArrangements" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_FacilityFees" abstract="false" name="FacilityFees" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_RestatementsAbstract" abstract="true" name="RestatementsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_ManufacturingCommercialization" abstract="false" name="ManufacturingCommercialization" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ManagementAndAdministrationExpense" abstract="false" name="ManagementAndAdministrationExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_JCRPharmaceuticalsCoLTDMember" abstract="true" name="JCRPharmaceuticalsCoLTDMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_RyoncilMember" abstract="true" name="RyoncilMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_RoyaltiesReceivableUnderSalesBasedMilestones" abstract="false" name="RoyaltiesReceivableUnderSalesBasedMilestones" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_RevenueFromSaleOfGoodsTotalGrossToNetAdjustmentsPercentage" abstract="false" name="RevenueFromSaleOfGoodsTotalGrossToNetAdjustmentsPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="meso_NumberOfCustomersWhichExceedTenPercentOfTotalRevenue" abstract="false" name="NumberOfCustomersWhichExceedTenPercentOfTotalRevenue" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="meso_CurrentTaxAbstract" abstract="true" name="CurrentTaxAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_IncreaseDecreaseInCurrentTax" abstract="false" name="IncreaseDecreaseInCurrentTax" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_IncreaseDecreaseInDeferredTaxAssets" abstract="false" name="IncreaseDecreaseInDeferredTaxAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_IncreaseDecreaseInDeferredTaxLiabilities" abstract="false" name="IncreaseDecreaseInDeferredTaxLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DeferredTaxAssetsNotBroughtToAccountForUnusedTaxLossesAbstract" abstract="true" name="DeferredTaxAssetsNotBroughtToAccountForUnusedTaxLossesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DeferredTaxAssetsNotBroughtToAccountForOtherTemporaryDifferencesAbstract" abstract="true" name="DeferredTaxAssetsNotBroughtToAccountForOtherTemporaryDifferencesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DeferredTaxAssetsNotBroughtToAccountForOtherTaxCreditsAbstract" abstract="true" name="DeferredTaxAssetsNotBroughtToAccountForOtherTaxCreditsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_OtherTaxCreditsForWhichNoDeferredTaxAssetRecognised" abstract="false" name="OtherTaxCreditsForWhichNoDeferredTaxAssetRecognised" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DeferredTaxAssetsNotBroughtToAccount" abstract="false" name="DeferredTaxAssetsNotBroughtToAccount" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DisclosureOfFinancialAssetsAndLiabilitiesTable" abstract="true" name="DisclosureOfFinancialAssetsAndLiabilitiesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfFinancialAssetsAndLiabilitiesLineItems" abstract="true" name="DisclosureOfFinancialAssetsAndLiabilitiesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_ContingentConsiderations" abstract="false" name="ContingentConsiderations" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DepositsAtCall" abstract="false" name="DepositsAtCall" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_InterestBearingDepositsAtCallHeldAsSecurity" abstract="false" name="InterestBearingDepositsAtCallHeldAsSecurity" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ForeignWithholdingTaxRecoverable" abstract="false" name="ForeignWithholdingTaxRecoverable" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_GovernmentChargebacks" abstract="false" name="GovernmentChargebacks" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ClinicalTrialResearchAndDevelopmentExpenditure" abstract="false" name="ClinicalTrialResearchAndDevelopmentExpenditure" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_PrepaidInsuranceAndSubscriptions" abstract="false" name="PrepaidInsuranceAndSubscriptions" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_OtherPrepayments" abstract="false" name="OtherPrepayments" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TradeReceivablesFromProductSalesSettlementPeriod" abstract="false" name="TradeReceivablesFromProductSalesSettlementPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_TradeAndOtherReceivablesSettlementPeriod" abstract="false" name="TradeAndOtherReceivablesSettlementPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_TradePayablesAndOtherPayables" abstract="false" name="TradePayablesAndOtherPayables" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_RefinancingAndExpansionOfSeniorDebtFacilityMember" abstract="true" name="RefinancingAndExpansionOfSeniorDebtFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_TrancheAxis" abstract="true" name="TrancheAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_TrancheDomain" abstract="true" name="TrancheDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_TrancheOneMember" abstract="true" name="TrancheOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_TrancheTwoMember" abstract="true" name="TrancheTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_QuarterlyPaymentsMember" abstract="true" name="QuarterlyPaymentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_November2021WarrantsMember" abstract="true" name="November2021WarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_FairValueOfWarrantsIssued" abstract="false" name="FairValueOfWarrantsIssued" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_WarrantExerciseTerm" abstract="false" name="WarrantExerciseTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_BorrowingsInterestOnlyPeriod" abstract="false" name="BorrowingsInterestOnlyPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_BorrowingsAmortizationOverPeriodPercentageOfPrincipal" abstract="false" name="BorrowingsAmortizationOverPeriodPercentageOfPrincipal" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_BorrowingsPrincipalAmortizationPeriod" abstract="false" name="BorrowingsPrincipalAmortizationPeriod" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_UnpaidInterestPortionPerAnnum" abstract="false" name="UnpaidInterestPortionPerAnnum" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_IssuanceWarrantsExercisedPeriod" abstract="false" name="IssuanceWarrantsExercisedPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_NumberOfWarrantsIssuedToPurchaseAmericanDepositaryShares" abstract="false" name="NumberOfWarrantsIssuedToPurchaseAmericanDepositaryShares" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_FinanceCostsGainsLossOnRemeasurementOfBorrowingArrangements" abstract="false" name="FinanceCostsGainsLossOnRemeasurementOfBorrowingArrangements" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_BorrowingsCovenantPercentageOfSalesExceedAnnualPaymentCap" abstract="false" name="BorrowingsCovenantPercentageOfSalesExceedAnnualPaymentCap" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="meso_IncreaseDecreaseInBorrowingsPrepayment" abstract="false" name="IncreaseDecreaseInBorrowingsPrepayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_LoanCovenantMinimumUnrestrictedCashBalance" abstract="false" name="LoanCovenantMinimumUnrestrictedCashBalance" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_BorrowingsRollForward" abstract="true" name="BorrowingsRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_CashFlowsAdjustmentsOnDebt" abstract="false" name="CashFlowsAdjustmentsOnDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_RemeasurementAdjustmentsOnDebt" abstract="false" name="RemeasurementAdjustmentsOnDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_IncreaseDecreaseInBorrowingLiabilitiesClassifiedAsFinancingActivities" abstract="false" name="IncreaseDecreaseInBorrowingLiabilitiesClassifiedAsFinancingActivities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_LeaseLiabilitiesRollForward" abstract="true" name="LeaseLiabilitiesRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_IncreaseDecreaseInLeaseLiabilitiesArisingFromFinancingActivities" abstract="false" name="IncreaseDecreaseInLeaseLiabilitiesArisingFromFinancingActivities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DecreaseInLiabilitiesFromFinancingActivitiesLeasesAcquisitions" abstract="false" name="DecreaseInLiabilitiesFromFinancingActivitiesLeasesAcquisitions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_IncreaseDecreaseThroughEffectOfChangesInForeignExchangeRatesLiabilitiesArisingFromLeases" abstract="false" name="IncreaseDecreaseThroughEffectOfChangesInForeignExchangeRatesLiabilitiesArisingFromLeases" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_WarrantLiabilityRollForward" abstract="true" name="WarrantLiabilityRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_IncreaseDecreaseFromWarrantyLiabilityClassifiedAsFinancingActivities" abstract="false" name="IncreaseDecreaseFromWarrantyLiabilityClassifiedAsFinancingActivities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_RemeasurementAdjustmentsOnWarrants" abstract="false" name="RemeasurementAdjustmentsOnWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_IncreaseDecreaseThroughEffectOfChangesInForeignExchangeRatesWarrantLiability" abstract="false" name="IncreaseDecreaseThroughEffectOfChangesInForeignExchangeRatesWarrantLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_SubTotalRollForward" abstract="true" name="SubTotalRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_RemeasurementAdjustmentsOnDebtAndWarrants" abstract="false" name="RemeasurementAdjustmentsOnDebtAndWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_OtherChangesOnDebtAndLeases" abstract="false" name="OtherChangesOnDebtAndLeases" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_CashAndCashEquivalentsRollForward" abstract="true" name="CashAndCashEquivalentsRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_TotalRollForward" abstract="true" name="TotalRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_EffectOfForeignExchangeAdjustmentsOnLiabilitiesArisingFromFinancingActivitiesAndCashAndCashEquivalents" abstract="false" name="EffectOfForeignExchangeAdjustmentsOnLiabilitiesArisingFromFinancingActivitiesAndCashAndCashEquivalents" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_UnlistedEquitySecuritiesMember" abstract="true" name="UnlistedEquitySecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ContingentConsiderationProvisionMember" abstract="true" name="ContingentConsiderationProvisionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_PercentageOfAssetsMeasuredAtFairValue" abstract="false" name="PercentageOfAssetsMeasuredAtFairValue" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_PercentageOfLiabilitiesMeasuredAtFairValue" abstract="false" name="PercentageOfLiabilitiesMeasuredAtFairValue" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_OsirisTherapeuticsInc.Member" abstract="true" name="OsirisTherapeuticsInc.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ContingentConsiderationRollForward" abstract="true" name="ContingentConsiderationRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_ContingentConsiderationProvision" abstract="false" name="ContingentConsiderationProvision" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ContingentConsiderationProvisionAmountPaid" abstract="false" name="ContingentConsiderationProvisionAmountPaid" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_GainsLossesOnRemeasurementOfContingentConsiderationChangesInKeyAssumptions" abstract="false" name="GainsLossesOnRemeasurementOfContingentConsiderationChangesInKeyAssumptions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_GainsLossesOnRemeasurementOfContingentConsiderationMilestonePayment" abstract="false" name="GainsLossesOnRemeasurementOfContingentConsiderationMilestonePayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ShareIssuedLockUpPeriod" abstract="false" name="ShareIssuedLockUpPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_ExpectedSalesVolumeMember" abstract="true" name="ExpectedSalesVolumeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ExpectedUnitSalesPriceMeasurementInputMember" abstract="true" name="ExpectedUnitSalesPriceMeasurementInputMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ExpectedSalesVolumesMeasurementInputMember" abstract="true" name="ExpectedSalesVolumesMeasurementInputMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ProbabilityOfSuccessMeasurementInputMember" abstract="true" name="ProbabilityOfSuccessMeasurementInputMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_PaymentAssumptionsMeasurementInputMember" abstract="true" name="PaymentAssumptionsMeasurementInputMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_PercentageOfWeightedAverageOfSignificantUnobservableInputsLiabilities" abstract="false" name="PercentageOfWeightedAverageOfSignificantUnobservableInputsLiabilities" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_PercentageOfReasonablyPossibleIncreaseDecreaseInUnobservableInputLiabilities" abstract="false" name="PercentageOfReasonablyPossibleIncreaseDecreaseInUnobservableInputLiabilities" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="meso_PercentageOfReasonablyPossibleIncreaseDecreaseInFairValueMeasurementDueToChangeInUnobservableInputLiabilities" abstract="false" name="PercentageOfReasonablyPossibleIncreaseDecreaseInFairValueMeasurementDueToChangeInUnobservableInputLiabilities" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="meso_CashOrStockPayableAtFairValueLiabilities" abstract="false" name="CashOrStockPayableAtFairValueLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_FinancialDerivativeLiabilityAtFairValueLiabilities" abstract="false" name="FinancialDerivativeLiabilityAtFairValueLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_RoyaltyPaymentsAtFairValueLiabilities" abstract="false" name="RoyaltyPaymentsAtFairValueLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_FairValuePerShare" abstract="false" name="FairValuePerShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="meso_NumberOfSharesIssuableAsContngentConsideration" abstract="false" name="NumberOfSharesIssuableAsContngentConsideration" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_WarrantLiabilityFairValueAtGrantDate" abstract="false" name="WarrantLiabilityFairValueAtGrantDate" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_WarrantLiabilityRemeasurement" abstract="false" name="WarrantLiabilityRemeasurement" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_WarrantLiabilityForeignCurrencyTranslationReserve" abstract="false" name="WarrantLiabilityForeignCurrencyTranslationReserve" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_WarrantLiabilityWarrantsExcercised" abstract="false" name="WarrantLiabilityWarrantsExcercised" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_December2022WarrantsMember" abstract="true" name="December2022WarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_NumberOfWarrantsExercised" abstract="false" name="NumberOfWarrantsExercised" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_NumberOfOrdinarySharesPerWarrant" abstract="false" name="NumberOfOrdinarySharesPerWarrant" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_WarrantsFairValueAtIssueDate" abstract="false" name="WarrantsFairValueAtIssueDate" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_GainLossOnRemeasurementOfWarrantLiability" abstract="false" name="GainLossOnRemeasurementOfWarrantLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_FairValuePerWarrant" abstract="false" name="FairValuePerWarrant" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="meso_FairValueOfWarrants" abstract="false" name="FairValueOfWarrants" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_IntangibleAssetsAndGoodwillRollForward" abstract="true" name="IntangibleAssetsAndGoodwillRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_CardiovascularProductsMember" abstract="true" name="CardiovascularProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_IntravenousProductsMember" abstract="true" name="IntravenousProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_EmployeeBenefits1Member" abstract="true" name="EmployeeBenefits1Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ProvisionForLicenseAgreementsMember" abstract="true" name="ProvisionForLicenseAgreementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ProvisionsAndOtherLiabilities" abstract="false" name="ProvisionsAndOtherLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_CurrentProvisionsForAccruedAnnualLeave" abstract="false" name="CurrentProvisionsForAccruedAnnualLeave" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_CurrentProvisionsForShortTermIncentives" abstract="false" name="CurrentProvisionsForShortTermIncentives" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DeferredTaxAssetsAbstract" abstract="true" name="DeferredTaxAssetsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DeferredTaxAssetsAttributableToTemporaryDifferencesFromTaxLosses" abstract="false" name="DeferredTaxAssetsAttributableToTemporaryDifferencesFromTaxLosses" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DeferredTaxAssetsAttributableToOtherTemporaryDifferences" abstract="false" name="DeferredTaxAssetsAttributableToOtherTemporaryDifferences" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DeferredTaxLiabilityAbstract" abstract="true" name="DeferredTaxLiabilityAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DeferredTaxLiabilitiesAttributableToTemporaryDifferencesFromIntangibleAssets" abstract="false" name="DeferredTaxLiabilitiesAttributableToTemporaryDifferencesFromIntangibleAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DeferredTaxAssetsAndLiabilitiesTable" abstract="true" name="DeferredTaxAssetsAndLiabilitiesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_TaxLossesMember" abstract="true" name="TaxLossesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_IntangibleAssetsMember" abstract="true" name="IntangibleAssetsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_DeferredTaxAssetsAndLiabilitiesLineItems" abstract="true" name="DeferredTaxAssetsAndLiabilitiesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DeferredTaxAssetsAndLiabilitiesRollForward" abstract="true" name="DeferredTaxAssetsAndLiabilitiesRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_DeferredTaxAssetsAndLiabilitiesRelatingToChargedOrCreditedAbstract" abstract="true" name="DeferredTaxAssetsAndLiabilitiesRelatingToChargedOrCreditedAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_NetMovementInRegulatoryDeferralAccountBalancesRelatedToDirectlyToEquity" abstract="false" name="NetMovementInRegulatoryDeferralAccountBalancesRelatedToDirectlyToEquity" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_InventoriesGross" abstract="false" name="InventoriesGross" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_InventoriesObsoleteStockProvision" abstract="false" name="InventoriesObsoleteStockProvision" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_RemeasurementOfWarrantLiabilities" abstract="false" name="RemeasurementOfWarrantLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_OtherNonCashCostOfFinanceClassifiedAsFinancingActivities" abstract="false" name="OtherNonCashCostOfFinanceClassifiedAsFinancingActivities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_AdjustmentForLossOnTerminationOfSublease" abstract="false" name="AdjustmentForLossOnTerminationOfSublease" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_AdjustmentForGainOnTerminationOfLease" abstract="false" name="AdjustmentForGainOnTerminationOfLease" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_FairValueRemeasurementOfContingentConsiderationAfterTax" abstract="false" name="FairValueRemeasurementOfContingentConsiderationAfterTax" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_AdjustmentsForRestructureOfShortTermIncentive" abstract="false" name="AdjustmentsForRestructureOfShortTermIncentive" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_AdjustmentForPreLaunchInventory" abstract="false" name="AdjustmentForPreLaunchInventory" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ChangeInOperatingAssetsAndLiabilitiesAbstract" abstract="true" name="ChangeInOperatingAssetsAndLiabilitiesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_AdjustmentsForIncreaseDecreaseInPrepayments" abstract="false" name="AdjustmentsForIncreaseDecreaseInPrepayments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_AdjustmentsForIncreaseDecreaseInTradeCreditorsAndAccruals" abstract="false" name="AdjustmentsForIncreaseDecreaseInTradeCreditorsAndAccruals" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TreasurySharesPurchased" abstract="false" name="TreasurySharesPurchased" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_OrdinarySharesPurchasedValue" abstract="false" name="OrdinarySharesPurchasedValue" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TreasurySharesPurchasedValue" abstract="false" name="TreasurySharesPurchasedValue" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_PlacementAgreementMember" abstract="true" name="PlacementAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_PrivatePlacementOfSharesMember" abstract="true" name="PrivatePlacementOfSharesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ChiefMedicalOfficerMember" abstract="true" name="ChiefMedicalOfficerMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_January2025WarrantsMember" abstract="true" name="January2025WarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ReconciliationOfShareCapitalNumberOfSharesAbstract" abstract="true" name="ReconciliationOfShareCapitalNumberOfSharesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_NumberOfSharesTransferredToEmployeeShareTrust" abstract="false" name="NumberOfSharesTransferredToEmployeeShareTrust" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_SharesAvailableForIssuanceUnderIssuancePlanShares" abstract="false" name="SharesAvailableForIssuanceUnderIssuancePlanShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_TransactionCostsArisingOnShareIssueShare" abstract="false" name="TransactionCostsArisingOnShareIssueShare" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_NumberOfSharesReservedForIssueUnderSharePlacementAgreement" abstract="false" name="NumberOfSharesReservedForIssueUnderSharePlacementAgreement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_NumberOfWarrantsExercisedShares" abstract="false" name="NumberOfWarrantsExercisedShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_NumberOfSharesUnissuedAndFullyPaid" abstract="false" name="NumberOfSharesUnissuedAndFullyPaid" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_ContributionsOfEquityDuringPeriodShares" abstract="false" name="ContributionsOfEquityDuringPeriodShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:decimalItemType"/>
  <xs:element id="meso_ShareOptionsReserveTransferredToEquityOnExerciseOfOptionsShares" abstract="false" name="ShareOptionsReserveTransferredToEquityOnExerciseOfOptionsShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_SharesTransferredToEmployeeShareTrustValue" abstract="false" name="SharesTransferredToEmployeeShareTrustValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_SharesReservedForIssueUnderSharePlacementAgreementValue" abstract="false" name="SharesReservedForIssueUnderSharePlacementAgreementValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TransactionCostsArisingOnShareIssueValue" abstract="false" name="TransactionCostsArisingOnShareIssueValue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_NumberOfSharesIssuedAndFullyPaidValue" abstract="false" name="NumberOfSharesIssuedAndFullyPaidValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_NumberOfUnissuedSharesReservedForIssueUnderSharePlacementAgreementValue" abstract="false" name="NumberOfUnissuedSharesReservedForIssueUnderSharePlacementAgreementValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_NumberOfSharesUnissuedValue" abstract="false" name="NumberOfSharesUnissuedValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ContributionsOfValueForEquityDuringPeriodValue" abstract="false" name="ContributionsOfValueForEquityDuringPeriodValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_ShareOptionsReserveTransferredToEquityOnExerciseOfOptionsValue" abstract="false" name="ShareOptionsReserveTransferredToEquityOnExerciseOfOptionsValue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_SaleOfEquityPricePerShare" abstract="false" name="SaleOfEquityPricePerShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="meso_DisclosureOfMovementsOfSharesInShareTrustTable" abstract="true" name="DisclosureOfMovementsOfSharesInShareTrustTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_MesoblastEmployeeShareTrustMember" abstract="true" name="MesoblastEmployeeShareTrustMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_DisclosureOfMovementsOfSharesInShareTrustLineItems" abstract="true" name="DisclosureOfMovementsOfSharesInShareTrustLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_MovementsOfSharesInShareTrustRollForward" abstract="true" name="MovementsOfSharesInShareTrustRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_SharesHeldInTrust" abstract="false" name="SharesHeldInTrust" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="meso_SharesHeldInTrustValue" abstract="false" name="SharesHeldInTrustValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TransferToEmployeeShareTrust" abstract="false" name="TransferToEmployeeShareTrust" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DisclosureOfWarrantReserveTable" abstract="true" name="DisclosureOfWarrantReserveTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_DisclosureOfWarrantReserveLineItems" abstract="true" name="DisclosureOfWarrantReserveLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_WarrantReserveActivityRollForward" abstract="true" name="WarrantReserveActivityRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_WarrantExercisePricePerShare" abstract="false" name="WarrantExercisePricePerShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="meso_SharesPrice" abstract="false" name="SharesPrice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:decimalItemType"/>
  <xs:element id="meso_SharePriceMinimumConsecutiveDay" abstract="false" name="SharePriceMinimumConsecutiveDay" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_DisclosureOfFinancialRiskManagementTable" abstract="true" name="DisclosureOfFinancialRiskManagementTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="meso_LonzaBioscienceSingaporePteLtdMember" abstract="true" name="LonzaBioscienceSingaporePteLtdMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_ManufacturingServiceAgreementMember" abstract="true" name="ManufacturingServiceAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_DisclosureOfFinancialRiskManagementLineItems" abstract="true" name="DisclosureOfFinancialRiskManagementLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="meso_PercentageOfCashHeld" abstract="false" name="PercentageOfCashHeld" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_EffectOnProfitFromChangeInInterestRate" abstract="false" name="EffectOnProfitFromChangeInInterestRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_PercentageOfForecastNetSales" abstract="false" name="PercentageOfForecastNetSales" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_NonInterestBearingFinancialLiabilitiesMaturityPeriod" abstract="false" name="NonInterestBearingFinancialLiabilitiesMaturityPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="meso_MinimumRemainingFinancialCommitmentOfNonLeaseComponentOnExerciseOfOptionToExtendNonCancellableTerm" abstract="false" name="MinimumRemainingFinancialCommitmentOfNonLeaseComponentOnExerciseOfOptionToExtendNonCancellableTerm" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_MinimumFinancialCommitmentOfLeaseComponentOnExerciseOfOptionToExtendNonCancellableTerm" abstract="false" name="MinimumFinancialCommitmentOfLeaseComponentOnExerciseOfOptionToExtendNonCancellableTerm" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_NonCancellablePurchaseCommitments" abstract="false" name="NonCancellablePurchaseCommitments" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_OtherPurchaseCommitments" abstract="false" name="OtherPurchaseCommitments" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_FundsInvestedPercentage" abstract="false" name="FundsInvestedPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_IncreaseInInterestRatePercentage" abstract="false" name="IncreaseInInterestRatePercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_DecreaseInInterestRatePercentage" abstract="false" name="DecreaseInInterestRatePercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_FundsInvestedWhichDerivesInterestRevenue" abstract="false" name="FundsInvestedWhichDerivesInterestRevenue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_IncreaseInInterestRateOnFundsInvestedWhichDerivesInterestRevenue" abstract="false" name="IncreaseInInterestRateOnFundsInvestedWhichDerivesInterestRevenue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_DecreaseInInterestRateOnFundsInvestedWhichDerivesInterestRevenue" abstract="false" name="DecreaseInInterestRateOnFundsInvestedWhichDerivesInterestRevenue" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_EffectOnProfitFromChangeInInterestRateIncreaseOrDecrease" abstract="false" name="EffectOnProfitFromChangeInInterestRateIncreaseOrDecrease" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_PercentageOfPriceRateChangesInCurrentBorrowings" abstract="false" name="PercentageOfPriceRateChangesInCurrentBorrowings" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_PercentageOfPriceRateChangesInNonCurrentBorrowings" abstract="false" name="PercentageOfPriceRateChangesInNonCurrentBorrowings" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_PercentageOfPriceRateChangesInBorrowings" abstract="false" name="PercentageOfPriceRateChangesInBorrowings" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_PercentageOfIncreaseAndDecreaseInSharePrice" abstract="false" name="PercentageOfIncreaseAndDecreaseInSharePrice" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="meso_SensitivityAnalysisForTypesOfMarketRiskReasonablyPossibleIncreaseInRiskVariableImpactOnEarningsWarrantLiability" abstract="false" name="SensitivityAnalysisForTypesOfMarketRiskReasonablyPossibleIncreaseInRiskVariableImpactOnEarningsWarrantLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_SensitivityAnalysisForTypesOfMarketRiskReasonablyPossibleDecreaseInRiskVariableImpactOnEarningsWarrantLiability" abstract="false" name="SensitivityAnalysisForTypesOfMarketRiskReasonablyPossibleDecreaseInRiskVariableImpactOnEarningsWarrantLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_SensitivityAnalysisForTypesOfMarketRiskReasonablyPossibleIncreaseInRiskVariableImpactOnEarningsDerivativeFinancialLiabilities" abstract="false" name="SensitivityAnalysisForTypesOfMarketRiskReasonablyPossibleIncreaseInRiskVariableImpactOnEarningsDerivativeFinancialLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_SensitivityAnalysisForTypesOfMarketRiskReasonablyPossibleDecreaseInRiskVariableImpactOnEarningsDerivativeFinancialLiability" abstract="false" name="SensitivityAnalysisForTypesOfMarketRiskReasonablyPossibleDecreaseInRiskVariableImpactOnEarningsDerivativeFinancialLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="meso_TradePayablesMember" abstract="true" name="TradePayablesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="meso_NumberOfOperatingSegment" abstract="false" name="NumberOfOperatingSegment" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
</xs:schema>
